https://ogma.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52060 Wed 27 Sep 2023 15:30:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52024 Wed 27 Sep 2023 09:55:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37737 Wed 24 May 2023 13:04:35 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:36629 Wed 24 Jun 2020 11:44:53 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4129 Wed 24 Jul 2013 22:23:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:40896 Wed 20 Jul 2022 13:52:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42028 Wed 17 Aug 2022 11:31:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37280 4) to organic oxygenates utilizing heterogeneous and homogeneous processes conducted in the gaseous or liquid phase is reviewed. The most active catalytic systems are examined in terms of rates, longevity, and reaction mechanisms. Despite significant effort, the successful heterogeneous mimicking of selective CH₄ oxidation performed in an enzymatic system (methane monooxygenase) is still elusive. Under mild reaction conditions, the reaction is too slow, and under harsh conditions, total oxidation prevails. Thus, of particular interest herein is the assessment of oxidation at intermediate temperatures to 1) reduce total oxidation and 2) obtain sufficient concentration of activated oxygen and CH₄ species. Important operational parameters such as reaction conditions, catalyst preparation methods, and cofeeding of chemicals, which significantly affect the yield of desired products, are discussed. One particular system that is successful is the catalytic conversion of CH₄ to methanol under mild conditions using nitrous oxide (N₂O) with Fe-based catalysts or oxygen (O₂) with Cu-based catalysts. Special attention is paid to the controversy related to the identification of active sites, where the oxygen species suitable for CH₄ oxidation are purportedly formed.]]> Wed 16 Sep 2020 18:36:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39093 Wed 13 Mar 2024 14:21:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42842 Wed 13 Mar 2024 11:23:21 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43650 Wed 13 Mar 2024 09:25:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45689 Wed 13 Mar 2024 08:51:20 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21314 Wed 11 Apr 2018 16:44:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22932 Wed 11 Apr 2018 16:16:56 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:1383 Wed 11 Apr 2018 15:51:49 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:6257 Wed 11 Apr 2018 15:40:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13655 Wed 11 Apr 2018 15:02:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18030 Wed 11 Apr 2018 14:49:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:10728 0.05). There was greater motility of CD151-transfected vs. control cells, when transferring through migration chambers with or without matrigel-coated membranes (P<0.01, P<0.01). Fewer numbers of mutant-transfected cells were found on the membranes for both migration and invasion studies (P<0.01, P<0.01). CD151 knock-down PC3 cells showed decreased motility (P<0.01), but no change in proliferation (P>0.05). Our data show that CD151 does not change the proliferative properties of prostate cancer cells, but does promote migration and invasion, and suggest that CD151 plays a specific role in promoting prostate cancer cell motility.]]> Wed 11 Apr 2018 14:15:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18024 Wed 11 Apr 2018 13:50:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:746 Wed 11 Apr 2018 13:35:14 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22603 Wed 11 Apr 2018 13:21:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20997 n = 144) in a multicultural high school in Western Sydney completed the asthma symptoms ISAAC video questionnaire (AVQ3.0), spirometry and allergy skin prick tests. A dietitian administered a 'Food Frequency' and 'Food Habits' questionnaire and a dietary history interview. Results: Students who spoke a language other than English, consumed a traditional or mixed dietary pattern, with lower consumption of saturated fat, compared to students who spoke English only. Saturated fat intake increased and fibre intake decreased with length of time in Australia. Intake of foods high in saturated or trans fatty acids were positively associated with length of stay in Australia. No associations between nutrient intake or whole food intake and self-reported wheeze were observed. Conclusion: As time progressed, dietary intake of immigrant children changed. While this was not associated with the development of wheeze in the students in this cohort, these changes are likely to have negative health consequences.]]> Wed 11 Apr 2018 11:16:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4103 Wed 11 Apr 2018 10:56:31 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24922 Calidris tenuirostris) during both northward and southward migration. Construction of a 33-km long sea-wall was completed in April 2006. We show that shorebird numbers at Saemangeum and two adjacent wetlands decreased by 130000 during northward migration in the next two years and that all species have declined at Saemangeum since completion of the sea-wall. Great Knots were among the most rapidly affected species. Fewer than 5000 shorebirds were recorded at Saemangeum during northward migration in 2014. We found no evidence to suggest that most shorebirds of any species displaced from Saemangeum successfully relocated to other sites in the ROK. Instead, by 2011-13 nearly all species had declined substantially in the ROK since previous national surveys in 1998 and 2008, especially at more heavily reclaimed sites. It is likely that these declines were driven by increased mortality rather than movement to alternate staging sites given that other studies have shown concurrent declines in numbers and survival on the non-breeding grounds. This is the first study in the East Asian-Australasian Flyway to confirm declines of shorebirds at a range of geographical scales following a single reclamation project. The results indicate that if migratory shorebirds are displaced from major staging sites by reclamation they are probably unable to relocate successfully to alternate sites.]]> Wed 11 Apr 2018 10:40:50 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:12683 Wed 11 Apr 2018 10:32:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:14383 Wed 11 Apr 2018 09:49:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:2251 Wed 11 Apr 2018 09:15:47 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52181 Wed 07 Feb 2024 15:21:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:37738 n = 58) and key informants (n = 20) in New York and Los Angeles, we analyze FOSTA/SESTA and its harmful effects as a launchpad to more broadly explore how technology, criminalization, shifting governance arrangements, and conservative moralities cohere to exacerbate sex worker's vulnerability.]]> Wed 07 Apr 2021 11:10:58 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31914 Wed 04 Apr 2018 11:56:44 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34594 Wed 02 Mar 2022 14:28:13 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45969 Tue 27 Feb 2024 14:05:27 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16085 Tue 24 Aug 2021 14:27:51 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32296 Tue 22 May 2018 14:02:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41959 Tue 16 Aug 2022 14:45:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46339 Penaeus [Melicertus] plebejus; EKP, an important penaeid species harvested across eastern Australia) that are closed to trawling (on a permanent, and temporary basis) were evaluated using a combination of trawl and tag-recapture surveys. Over 1,250 EKP were tagged and released across the permanent and temporary trawl closure, and 15.4% of all tagged prawns were recaptured and reported by fishers in both New South Wales (33% of recaptures) and the adjacent jurisdiction of Queensland (67% of recaptures, up to 730 km from the point of tagging) during 7 months post-tagging. There were significant differences in prawn size and abundance across the permanent and temporary trawl closure areas with both depth and distance to the adjacent estuarine nursery explaining these patterns, but prawns generally exceeded the minimum size-at-first-capture estimated by relevant yield per recruit models before they left areas closed to trawling. While more prawns were captured in Queensland, recapture rates were far greater in New South Wales when standardised by relative effort. Patterns in these data highlight the broader considerations of spatial management in multi-jurisdictional fisheries.]]> Tue 15 Nov 2022 13:51:54 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35129 Tue 09 May 2023 15:52:02 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38809 N-player social dilemma game. Players in the population are divided into non-overlapped groups, and they can choose to either cooperate or defect within their group. At the same time, the players are mapped to the nodes of a scale-free network, enabling them to learn from the actions of players from other groups. Every player is allowed to migrate between groups, and their migration decisions are governed by the risk from climate change at the current group, as well as their ability to adapt. We introduce a cooperation threshold to ensure that a minimum percentage of players cooperate before any benefit can be achieved within a group. Comprehensive simulation experiments show that migration has a positive impact on the level of cooperation, and the cooperative behaviour observed is proportional to the threshold level. This study contributes by being one of the first to study climate change induced migration using evolutionary game theory. Our findings also contribute to the understanding of the impact of cooperation thresholds in promoting cooperative behaviour in multi-player social dilemma games, where players are allowed to migrate.]]> Tue 08 Feb 2022 12:24:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:35651 84 cell monolayers grown on transparent, permeable supports was assessed over 48 h with or without bile acids. Cell migration was measured in Boyden chambers. mRNA and protein expression were measured by RT-PCR and Western blotting. DCA (50-150 μM) significantly inhibited wound closure in cultured epithelial monolayers and attenuated cell migration in Boyden chamber assays. DCA also induced nuclear accumulation of the farnesoid X receptor (FXR), whereas an FXR agonist, GW4064 (10 µM), inhibited wound closure. Both DCA and GW4064 attenuated the expression of CFTR Cl⁻ channels, whereas inhibition of CFTR activity with either CFTR-_inh-172 (10 μM) or GlyH-101 (25 µM) also prevented wound healing. Promoter/reporter assays revealed that FXR-induced downregulation of CFTR is mediated at the transcriptional level. In contrast, UDCA (50-150 µM) enhanced wound healing in vitro and prevented the effects of DCA. Finally, DCA inhibited and UDCA promoted mucosal healing in an in vivo mouse model. In conclusion, these studies suggest bile acids are important regulators of epithelial wound healing and are therefore good targets for development of new drugs to modulate intestinal barrier function in disease treatment. New & Noteworthy: The secondary bile acid, deoxycholic acid, inhibits colonic epithelial wound healing, an effect which appears to be mediated by activation of the nuclear bile acid receptor, FXR, with subsequent downregulation of CFTR expression and activity. In contrast, ursodeoxycholic acid promotes wound healing, suggesting it may provide an alternative approach to prevent the losses of barrier function that are associated with mucosal inflammation in IBD patients.]]> Tue 01 Oct 2019 13:39:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34242 Thu 28 Oct 2021 12:35:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:17 Thu 25 Jul 2013 09:10:08 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:187 Thu 25 Jul 2013 09:09:30 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46478 Thu 24 Nov 2022 08:50:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44700 Thu 20 Oct 2022 10:12:50 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38252 Thu 19 Aug 2021 11:04:32 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:43345 Thu 15 Sep 2022 15:18:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:54264 Thu 15 Feb 2024 14:31:17 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39933 Thu 14 Jul 2022 10:23:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:55562 Thu 06 Jun 2024 13:58:29 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5960 Sat 24 Mar 2018 11:04:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31634 Sat 24 Mar 2018 08:45:06 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:9702 Sat 24 Mar 2018 08:34:38 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8076 Sat 24 Mar 2018 08:34:26 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11355 Sat 24 Mar 2018 08:11:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16504 Sat 24 Mar 2018 08:04:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16664 Sat 24 Mar 2018 07:59:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16659 Sat 24 Mar 2018 07:59:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16657 Sat 24 Mar 2018 07:59:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:16676 Sat 24 Mar 2018 07:59:39 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:20990 Sat 24 Mar 2018 07:50:42 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:5871 Sat 24 Mar 2018 07:44:59 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:3834 Sat 24 Mar 2018 07:21:46 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23532 Sat 24 Mar 2018 07:16:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48175 Sat 11 Mar 2023 12:23:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32903 Mon 23 Sep 2019 14:09:38 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49577 Mon 22 May 2023 10:51:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:32287 Mon 21 May 2018 13:53:00 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46212 Penaeus (Melicertus) plebejus; EKP) as a case study, we examine how spatial and temporal factors can influence connectivity between a spatial management network designed to protect small prawns from capture by trawlers, and a multi-jurisdictional (Queensland [Qld] and New South Wales [NSW]) fishery. Over 7500 prawns were tagged across multiple years in three northern NSW spatial management areas, and 786 tagged prawns were recaptured across both jurisdictions. The majority of prawns tended to be recaptured from deeper waters adjacent to, or directly north of, the spatial management areas, but tagging location and release timing influenced recapture patterns. Cohorts tagged early in the growth season showed lower recapture rates, but were larger on average at recapture, and had migrated further. Prawns reached the fishery in the adjacent jurisdiction (Qld) within 54 days-post tagging, but for most cohorts the majority of recaptures were in NSW zones. Overall, there was good connectivity between all spatial management areas and the NSW fishery, and tagged prawns also reached the Qld spawning areas. This represents an optimal scenario for NSW fishers (who forgo capture of prawns within these spatial management areas): the prawns protected in the closure areas primarily contribute to harvest of larger sized prawns within NSW waters; and a portion of the protected prawns survive to reach the southern Queensland spawning grounds, which is the primary source of recruits for northern NSW nurseries. These findings are broadly relevant to defining the role and impact of established and proposed spatial management networks within penaeid fisheries.]]> Mon 14 Nov 2022 15:47:10 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44184 Mon 10 Oct 2022 10:48:32 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39586 in silico using the Kaplan-Meier Plotter (n=3,935), the TCGA invasive breast carcinoma (n=960) and GOBO (n=821) data sets. Functional effects of BAALC expression on breast cancer proliferation, migration and invasion were determined in vitro. We demonstrate herein that BAALC expression is progressively increased in primary and breast cancer metastases when compared to normal breast tissue. Increased BAALC mRNA is associated with a reduction in DMFS and disease-free survival, but not OS, in breast cancer patients, even when corrected for tumor grade. We show that overexpression of BAALC in MCF-7 breast cancer cells increases the proliferation, anchorage-independent growth, invasion, and migration capacity of these cells. Conversely, siRNA knockdown of BAALC expression in Hs578T breast cancer cells decreases proliferation, invasion and migration. We identify that this BAALC associated migration and invasion is mediated by focal adhesion kinase (FAK)-dependent signaling and is accompanied by an increase in matrix metalloproteinase (MMP)-9 but not MMP-2 activity in vitro. Our data demonstrate a novel function for BAALC in the control of breast cancer metastasis, offering a potential target for the generation of anti-cancer drugs to prevent breast cancer metastasis.]]> Mon 08 Aug 2022 11:48:18 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41224 Fri 29 Jul 2022 10:25:19 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:25422 Fri 22 Apr 2022 10:34:13 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52684 Fri 20 Oct 2023 09:58:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44523 Fri 18 Aug 2023 14:11:36 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11277 Fri 07 Dec 2018 16:16:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49107 Fri 05 May 2023 11:32:08 AEST ]]>